About CARES Study

The CARES Study aims to improve HIV pre-exposure prophylaxis (PrEP) adherence and continuation among adolescent girls and young women (AGYW) aged 16–24 in Zimbabwe. Funded by the National Institute of Mental Health (NIMH), the study adapts the Comprehensive Adherence Resource and Empowerment Support (CARES) intervention to support effective use of oral, vaginal ring and injectable PrEP.

Through qualitative research, community engagement and intervention testing, the study works with AGYW, healthcare providers and key stakeholders to develop practical, sustainable adherence support approaches for routine healthcare settings.

Objectives

  • Adapt the CARES intervention for real-world delivery to improve PrEP adherence.
  • Assess its effectiveness in improving PrEP continuation and adherence among AGYW.
  • Evaluate the feasibility, acceptability and fidelity of CARES in routine healthcare settings.

Focus Area

The study uses focus group discussions, key informant interviews and participatory adaptation workshops to develop youth-responsive PrEP adherence support tools. It also assesses PrEP use, adherence support and intervention implementation to inform sustainable HIV prevention services.

  • Study Sites: Chitungwiza and Cowdray Park Clinic

  • Key Informant Interviews

  • AGYW Focus Group Participations

  • Years Study Duration