The goal is to improve individual and population health and the quality of life for all population groups in their intersecting identities. Initially, with a primary focus on HIV and Sexual and Reproductive Health and Rights (SRHR), the organization has evolved over the years to focus on broader health issues at global south, national and subnational levels. Key areas of focus include movement building for; health systems strengthening, improving the quality of primary healthcare for underserved and vulnerable population groups, advocacy, capacity strengthening and development of emerging organisations, research, program monitoring, and evaluation and community systems strengthening.

PZ promotes evidence-driven strategies to expand access to health services whilst upholding the rights of all citizens regardless of circumstances of birth, gender, sexual orientation, or geography. We recognize that decision makers, local leaders and communities are central to forging resilient health and community systems in responding to and addressing health issues and as such, we prioritize partnering with global, regional, national, local structures and communities to promote ownership and sustainability.